![]() Antigen–antibody binding, which can cause skin diseases, can also induce conditions such as degranulation of the mast cells in the skin, and vasoactive mediators such as histamine, prostaglandins, and leukotrienes are released that may cause skin microcirculation disorders 5.Ĭhronic urticaria can also arise as a systemic inflammatory response involving T cell-mediated cellular immune responses in addition to peripheral innate immune responses at the time of onset. Unlike NICU, which is not dependent on a specific antibody to the causative agent, ICU involves antigens binding to the immunoglobulin E (IgE)-specific antibodies of mast cells located in the dermis 3, 4. ![]() CU can be classified into two types: non-immune contact urticaria (NICU) and immune contact urticaria (ICU), a rash and flare-up reaction caused by direct contact with a symptomatic chemical or protein substance 2. Similar content being viewed by othersĬontact urticaria (CU) is known to be a typical chronic inflammatory skin disease that causes itching, redness, swelling, and cracked skin lesions 1. Additionally, we suggest that TGF-β derived from M-MSCs could play a pivotal role as an inhibitory mechanism in contact urticaria. Our study demonstrates the capacity of M-MSCs to regulate contact urticaria in a murine model, harmonizing the activation of inflammatory T cells and mast cells. Notably, the inhibitory effects mediated by M-MSCs were found to be TGF-β-dependent. ![]() Moreover, M-MSC administration exerted control over effector T cell activities in major lymphoid and peripheral tissues, while also suppressing mast cell degranulation in peripheral tissues. Therapeutic effects of M-MSC administration were assessed in a Trimellitic anhydride-induced contact urticaria model, revealing significant inhibition of urticarial reactions, including ear swelling, itchiness, and skin lesion. This study investigates the regulatory role of embryonic-stem-cell-derived multipotent MSCs (M-MSCs) administered in a CU mouse model. ![]() While mesenchymal stem cells (MSCs) are increasingly recognized for their therapeutic potential in immune diseases, research on the efficacy and mechanisms of stem cell therapy for urticaria remains scarce. Contact urticaria (CU) is an inflammatory skin disorder triggered by specific substances upon skin contact, leading to immediate acute or chronic manifestations characterized by swelling and redness. ![]()
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